Renal function

CKD-EPI 2021 (Cr + Cystatin C)

Combined creatinine + cystatin C equation. Recommended confirmation when eGFRcr 45-59 (CKD diagnostic uncertainty).

eGFRcystatin C

Required inputs

  • Age
  • Sex
  • Serum creatinine
  • Cystatin C (mg/L)

Equation or source

Inker LA, NEJM 2021;385:1737.

Provenance and release status

Equation / algorithm
Combined creatinine + cystatin C equation. Recommended confirmation when eGFRcr 45-59 (CKD diagnostic uncertainty).
Formula version
ckd-epi-2021-crcys-v1
Tool version
2.4.0
Clinical risk class
B. CLINICAL DECISION-SUPPORT CALCULATOR
Release status
Under clinical review
Source status
Direct primary or authoritative source identifier resolved
Clinical review status
Under clinical verification
Clinical review date
Clinical review date not yet documented

Assumptions

  • Entered values and units are accurate and apply to the population described by the cited source.
  • The published equation or rule is being used without a patient-specific clinical adjustment.

Important limitations

  • The result does not replace clinical assessment or establish a diagnosis.
  • Performance outside the source population may differ.
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