Vancomycin starting dose (adult)

Required inputs

• Body weight (kg)
• CrCl or eGFR (mL/min)
• Severe MRSA (endocarditis, bacteremia, meningitis, pneumonia)

Equation or source

Rybak MJ. AJHP 2020;77:835. Use AUC₂₄/MIC 400-600 target.

Provenance and release status

Equation / algorithm

Loading + maintenance per ASHP/IDSA 2020 AUC-guided dosing.

Formula version

vanc-2020-v1

Tool version

2.4.0

Clinical risk class

C. HIGH-RISK CLINICAL CALCULATOR

Release status

Temporarily unavailable

Source status

Direct primary or authoritative source identifier resolved

Clinical review status

Clinical verification incomplete; active calculation unavailable

Clinical review date

Clinical review date not yet documented

• PMID 32191793
• DOI 10.1093/ajhp/zxaa036

Assumptions

• Entered values and units are accurate and apply to the population described by the cited source.
• The published equation or rule is being used without a patient-specific clinical adjustment.

Important limitations

• The result is a calculated estimate, not a prescription, treatment order, or diagnosis.
• Local protocols, the full clinical context, and the primary source must be checked before use.