06

HEMODIALYSIS & EXTRACORPOREAL THERAPY

Chapter 6

AV Grafts and the Tunneled

Catheter

Orientation & KnowledgeVisualise & MapClinical ReasoningSafety & EvidencePatient DecisionsApply & Test
Chapter Preamble

This preamble records the dynamic decisions the master makes for this chapter.

Signals declared

  • Sig-P procedural (primary) — the chapter covers graft placement and cannulation, catheter insertion, locking, and dysfunction management.
  • Sig-D diagnostic — it classifies graft and catheter options and the causes of dysfunction.

Levels populated and omitted

  • Sixteen levels are built — a procedure-and-diagnosis chapter focused on the technique of grafts and catheters.
  • Omitted: L6 concept maps and L9 implications triads — no mechanistic-physiology signal. L14–L16 and L21 — the values-driven access-selection decisions live in the preceding chapter (The AV Fistula & Access Planning); access infection is cross-referenced to its own chapter.
Phase A Orientation & Knowledge
01
Phase A · Level 1

Learning Objectives

The contract between this chapter and the reader.

  1. 1. State when an AV graft is chosen over a fistula or a catheter.
  2. 2. Describe graft configurations and the venous-anastomosis stenosis problem.
  3. 3. Compare graft and fistula by time-to-use, patency, and complications.
  4. 4. Choose a tunneled catheter site and explain why the subclavian is avoided.
  5. 5. Distinguish tunneled-cuffed from non-tunneled temporary catheters.
  6. 6. Manage catheter dysfunction — thrombosis, fibrin sheath, and malposition.
  7. 7. Use catheter locking solutions appropriately.
  8. 8. Cannulate a graft safely.
02
Phase A · Level 2

Executive Summary

A sixty-second reading. Each bullet stands alone.

  • An AV graft is a synthetic conduit joining an artery to a vein when the veins are inadequate for a fistula.
  • A graft is usable sooner than a fistula and needs no maturation, but it clots and stenoses more and needs more interventions.
  • Graft stenosis classically forms at the venous anastomosis from neointimal hyperplasia.
  • A graft's infection risk sits between a fistula (lowest) and a catheter (highest).
  • A tunneled cuffed catheter is used when a fistula or graft is not possible or not yet ready, or as a bridge.
  • The right internal jugular is the preferred catheter site; the subclavian is avoided because it causes central stenosis.
  • Tunneling and a Dacron cuff reduce catheter infection and dislodgement compared with a temporary line.
  • The catheter tip sits at the cavoatrial junction for reliable flow.
  • Between sessions the catheter is locked — with heparin or citrate — to prevent thrombosis.
  • Poor catheter flow is usually thrombosis, a fibrin sheath, or malposition; a thrombolytic lock often restores it.
  • Reversing the catheter lines restores flow but causes recirculation and is only a temporary measure.
  • Cannulate grafts by rope-ladder and not before they are incorporated.
03
Phase A · Level 3

Main Narrative

The medical core. An expert should agree grafts and catheters are fully covered here.

Why it matters at the bedside

When a fistula is not possible, the choice is a graft or a catheter — and the two could not be more different. A graft is a durable, cannulatable conduit that clots; a catheter works the instant it is placed and quietly drives infection and central stenosis. Knowing the technique and the failure modes of each is what keeps a patient dialysing safely.

The AV graft: when and what

  • An AV graft — usually expanded PTFE — bridges an artery to a vein when the native veins are too small or poor for a fistula but the inflow artery and outflow vein are adequate. It is chosen over a catheter whenever feasible, because its infection and mortality risk are lower.
  • Common configurations are a forearm loop, an upper-arm straight or loop graft, and — as a last resort — a thigh graft, which carries a higher infection risk.

Graft patency and the venous-anastomosis problem

  • A graft needs no maturation — it is a tube — so it is usable within about two weeks (early-cannulation grafts within days). The trade-off is durability: grafts clot and stenose more than fistulae and need more interventions.
  • The characteristic lesion is neointimal hyperplasia at the venous anastomosis, which narrows over time, lowers flow, and eventually thromboses unless found and treated. Falling flow is the warning, and it is surveilled.

Graft cannulation

  • Do not cannulate a standard graft before it has incorporated into the surrounding tissue — about two weeks — or a haematoma will form; early-cannulation grafts are the exception. Once usable, rope-ladder the punctures along the graft; repeated area puncture causes pseudoaneurysm.

The tunneled catheter: when and where

  • A tunneled cuffed catheter is the access when a fistula or graft is impossible or not yet ready, or as a deliberate bridge. Site matters: the right internal jugular is preferred for its straight path and lowest stenosis and thrombosis; the left internal jugular is second; the femoral vein is for temporary use and is infection-prone.
  • The subclavian vein is avoided for chronic access because it causes central venous stenosis that can ruin the entire arm for a future fistula or graft.

Catheter type and tip

  • A tunnel and a Dacron cuff anchor the catheter and lower infection and dislodgement, which is why a tunneled cuffed catheter is used for anything beyond short-term needs; a non-tunneled temporary catheter is acceptable only for acute, brief use. The tip is positioned at the cavoatrial junction for reliable high flow.

Locking the catheter

  • Between sessions the lumens are filled with a locking solution — heparin or citrate — to prevent thrombosis, with an antimicrobial lock reserved for selected high-risk patients.

Catheter dysfunction and its management

  • Poor flow is the common problem. The usual causes are an intraluminal thrombus, a fibrin sheath at the tip, or malposition or kinking. A thrombolytic (alteplase) lock often restores flow; recurrent dysfunction from a fibrin sheath is managed by stripping or exchanging the catheter over a guidewire, and malposition by repositioning. Reversing the lines restores numbers but causes recirculation and is only a stopgap.

Insertion technique and confirmation

  • Catheters are placed under ultrasound guidance for the venous puncture and fluoroscopy for tip position, tunneled with the cuff in the subcutaneous track, and confirmed by flow and a chest radiograph for tip position and to exclude pneumothorax.

Complications

  • Beyond dysfunction, the dominant catheter hazards are bloodstream infection (covered in the access-infection chapter), thrombosis, and central venous stenosis; grafts add thrombosis, pseudoaneurysm, and steal. These are why a graft is preferred to a catheter, and a fistula to both.
04
Phase A · Level 4

Reference Tables

Five fully-built tables.

Table A — Graft versus fistula

FeatureAV graftAV fistula
Time to use~2 weeks (early-cannulation: days)Weeks to months (maturation)
PatencyLower; more interventionsHigher long-term
Stenosis siteVenous anastomosis (neointimal hyperplasia)Juxta-anastomotic
InfectionIntermediateLowest
MaterialSynthetic (ePTFE)Native vessels

Table B — Graft configurations

ConfigurationNote
Forearm loopCommon first graft
Upper-arm straight / loopWhen the forearm is unsuitable
Thigh (femoral) graftLast resort; higher infection

Table C — Tunneled catheter sites

SiteNote
Right internal jugularPreferred — straight path, least stenosis/thrombosis
Left internal jugularSecond choice
FemoralTemporary; higher infection
SubclavianAvoid — central stenosis (ruins the arm)

Table D — Catheter dysfunction

CauseClueManagement
Intraluminal thrombusSudden poor flowThrombolytic (alteplase) lock
Fibrin sheathRecurrent poor flow; aspiration/infusion mismatchStrip or exchange over a wire
Malposition / kinkPositional flowReposition; chest radiograph
Lines reversedLower delivered doseTemporary only — fix the cause

Table E — Locking and care

ElementNote
Inter-dialytic lockHeparin or citrate to prevent thrombosis
Antimicrobial lockSelected high-risk patients
Tip positionCavoatrial junction for flow
CuffDacron cuff — ingrowth; fewer infections/dislodgement
Graft cannulationRope-ladder after incorporation

Visualise & Map

Phase B Visualise & Map
05
Phase B · Level 5

Imaging and Algorithm Flowcharts

Figure 6.1 — Graft configurations
Figure 6.1 — Graft configurations
Figure 6.2 — The tunneled cuffed catheter
Figure 6.2 — The tunneled cuffed catheter
Flowchart 6.A — Graft or catheter
Flowchart 6.A — Graft or catheter
Flowchart 6.B — The poorly flowing catheter
Flowchart 6.B — The poorly flowing catheter
07
Phase B · Level 7

Clinical Decision Pathways

Numbered rules. These numbers are the cross-reference handle for the cases and flowcharts.

R1
IF the veins are inadequate for a fistula but the inflow artery and outflow vein are adequate, THEN choose a graft over a catheter.
R2
IF a graft is placed, THEN expect venous-anastomosis stenosis and surveil the flow for decline.
R3
IF cannulating a graft, THEN wait for incorporation (standard ~2 weeks) and use rope-ladder.
R4
IF a tunneled catheter is needed, THEN use the right internal jugular and avoid the subclavian vein.
R5
IF the need is short-term, THEN a non-tunneled temporary catheter is acceptable; for longer use, tunnel and cuff it.
R6
IF catheter flow is poor, THEN suspect thrombosis, a fibrin sheath, or malposition, and try a thrombolytic lock.
R7
IF a thrombolytic lock fails, THEN consider fibrin-sheath stripping or catheter exchange over a guidewire.
R8
IF locking the catheter between sessions, THEN use heparin or citrate.
R9
IF the catheter tip is malpositioned, THEN reposition it to the cavoatrial junction.

Clinical Reasoning

Phase C Clinical Reasoning
08
Phase C · Level 8

Clinical Cases

Four cases. Each stops you at a decision before it answers it.

CASE 1STANDARD

Veins too small for a fistulaChoosing a graft over a catheter

Presentation

A patient needs long-term access. Vein mapping shows veins too small for a fistula, but a good inflow artery and an adequate outflow vein.

Pause and reflect

Before reading on: graft or catheter — and why?

Analysis

With inadequate veins for a fistula but adequate inflow and outflow, a graft is the right durable choice and is preferred over a catheter for its lower infection and mortality. A forearm loop is a reasonable first configuration, cannulated after incorporation.

Management plan

  1. Place an AV graft rather than default to a catheter (R1).
  2. Choose a forearm loop where feasible; surveil flow (R2).
  3. Cannulate after ~2 weeks by rope-ladder (R3).

Teaching points

  • If a graft is feasible, it beats a catheter — lower infection and mortality.

Cross-reference: exercises R1, R2, R3.

CASE 2COMPLEX

The graft flow is fallingVenous-anastomosis stenosis

Presentation

A forearm graft shows steadily falling flow on surveillance, with a high-pitched bruit over the venous end and prolonged bleeding after needle removal.

Pause and reflect

Before reading on: where is the lesion, and what happens if you ignore it?

Analysis

Falling flow with a high-pitched venous-end bruit is the signature of neointimal hyperplasia at the venous anastomosis — the graft's characteristic lesion. Left alone it progresses to thrombosis and graft loss; found early, it is treated by angioplasty.

Management plan

  1. Localise the lesion to the venous anastomosis (R2).
  2. Refer for angioplasty before thrombosis.
  3. Continue flow surveillance afterward.

Teaching points

  • Falling graft flow points to venous-anastomosis stenosis — treat before it clots.

Cross-reference: exercises R2.

CASE 3COMPLEX

The catheter won't flowWorking up dysfunction

Presentation

A tunneled catheter gives poor flow at the start of dialysis. The chest radiograph shows a well-positioned tip. A thrombolytic lock restores flow, but the problem recurs over the following weeks.

Pause and reflect

Before reading on: the tip is fine and lock works briefly — what is the recurrent cause?

Analysis

A well-positioned tip rules out malposition; a thrombolytic lock that works transiently and recurrently points to a fibrin sheath at the tip. The durable fix is stripping or exchanging the catheter over a guidewire, not repeated reversing of the lines, which only adds recirculation.

Management plan

  1. Exclude malposition on the radiograph (R9).
  2. Try a thrombolytic lock; note the recurrence (R6).
  3. For a fibrin sheath, strip or exchange over a wire (R7).

Teaching points

  • Recurrent dysfunction with a good tip and transient lock response = fibrin sheath.

Cross-reference: exercises R6, R7, R9.

CASE 4STANDARD

Reaching for the subclavianThe wrong catheter site

Presentation

A team is about to place a tunneled catheter via the subclavian vein in a patient who will likely need a fistula or graft in that arm later.

Pause and reflect

Before reading on: what is wrong with the subclavian route here?

Analysis

The subclavian vein scars and stenoses centrally, and that stenosis can ruin the entire arm for a future fistula or graft. The right internal jugular is preferred for its straight path and far lower rate of central stenosis. The site choice protects the patient's access future.

Management plan

  1. Avoid the subclavian; use the right internal jugular (R4).
  2. Tunnel and cuff for anything beyond short-term use (R5).
  3. Confirm tip at the cavoatrial junction (R9).

Teaching points

  • Never choose the subclavian for chronic access — central stenosis costs an arm.

Cross-reference: exercises R4, R5, R9.

10
Phase C · Level 10

Clinical Pearls

Exhaustive. Every rule in the chapter is here.

Graft = synthetic artery-to-vein conduit when veins are too poor for a fistula.
Graft usable ~2 weeks (early-cannulation: days); no maturation.
Graft trade-off: more clotting, stenosis, interventions than a fistula.
Graft stenosis = venous anastomosis (neointimal hyperplasia).
Graft infection: between fistula (lowest) and catheter (highest).
If a graft is feasible, choose it over a catheter.
Catheter sites: right IJ > left IJ > femoral; avoid subclavian.
Subclavian = central stenosis = ruins the arm.
Tunnel + Dacron cuff = fewer infections/dislodgement.
Tip at the cavoatrial junction for flow.
Lock between sessions with heparin or citrate.
Poor flow: thrombus, fibrin sheath, or malposition.
Thrombolytic lock first; recurrent = fibrin sheath → strip/exchange.
Reversing lines = recirculation — temporary only.
Cannulate grafts after incorporation; rope-ladder, not area puncture.
Falling graft flow → surveil and angioplasty before thrombosis.

Safety & Evidence

Phase D Safety & Evidence
11
Phase D · Level 11

Red Flags and NEVER DO

Panel A — Red flags

Steadily falling graft flow or a high-pitched venous-end bruit — venous-anastomosis stenosis.
Arm or facial swelling — central venous stenosis (often from a prior subclavian line).
Recurrent catheter dysfunction despite locks — fibrin sheath.
Fever or rigors with a catheter — catheter-related bloodstream infection (see the access-infection chapter).

Panel B — NEVER DO

NEVER — place a subclavian tunneled catheter for chronic access.
NEVER — cannulate a standard graft before it has incorporated.
NEVER — use area puncture on a graft — it causes pseudoaneurysm.
NEVER — accept reversed lines as a permanent fix for poor flow.
NEVER — ignore a declining graft flow on surveillance.
12
Phase D · Level 12

Common Pitfalls

Anti-patterns clinicians fall into. Each becomes a Level 22 distractor.

WRONG Placing a catheter when a graft is feasible.
RIGHT Choose a graft over a catheter.
WHY A graft has lower infection and mortality than a catheter.
WRONG Using the subclavian vein for a tunneled catheter.
RIGHT Use the right internal jugular.
WHY The subclavian causes central stenosis that ruins the arm.
WRONG Cannulating a graft before it has incorporated.
RIGHT Wait ~2 weeks (standard graft) and rope-ladder.
WHY Early cannulation causes haematoma and damage.
WRONG Reversing the catheter lines as a lasting solution.
RIGHT Treat the cause — thrombolytic, then strip/exchange.
WHY Reversed lines recirculate and cut the delivered dose.
WRONG Ignoring a falling graft flow.
RIGHT Surveil and angioplasty the venous anastomosis.
WHY Untreated stenosis progresses to thrombosis and graft loss.
WRONG Area puncture of a graft.
RIGHT Rope-ladder along the graft.
WHY Area puncture causes pseudoaneurysm.
13
Phase D · Level 13

Evidence Grading

The grade reflects strength of evidence, not importance.

GRADE

A

HIGH CONFIDENCE

The effect is real and the estimate is stable.

RCTs at low risk of bias; multiple concordant prospective cohorts; meta-analyses.

GRADE

B

MODERATE CONFIDENCE

The effect is likely real but may shift with new data.

Observational studies, registries, mechanistic human studies.

GRADE

C

LOW CONFIDENCE

Rests on physiology, reasoning, or consensus rather than outcomes.

Pathophysiological reasoning; extrapolation; consensus without outcomes.

StatementGradeRationale for the grade
Grafts are usable sooner but have lower patency and more interventions than fistulae.BConsistent observational data.
Graft infection risk lies between fistula and catheter.BObservational data.
The subclavian route causes central stenosis; the right IJ is preferred.BObservational and consensus data.
A thrombolytic lock restores flow in catheter thrombosis.BTrials and observational data.
Tunneled-cuffed catheters have lower infection than temporary lines.BObservational data.
Neointimal hyperplasia at the venous anastomosis drives graft stenosis.BHistology and observational data.

Apply & Test

Phase F Apply & Test
17
Phase F · Level 17

Documentation Templates

Copy-paste chart notes that map to the real procedures in this chapter.

Template 1 — Tunneled catheter insertion note

  • Indication: bridge / no fistula or graft / by choice; consent obtained.
  • Site: right IJ / left IJ / femoral (subclavian avoided); ultrasound-guided puncture.
  • Catheter: tunneled cuffed / temporary; tip confirmed at cavoatrial junction (fluoroscopy).
  • Flow confirmed: yes/no; chest radiograph (tip / pneumothorax): ___.
  • Lock instilled: heparin / citrate; complications: none / ___.

Template 2 — Catheter dysfunction management note

  • Problem: poor flow at ___; positional? yes/no.
  • Imaging: tip position ___; kink ___.
  • Working cause: thrombus / fibrin sheath / malposition.
  • Action: thrombolytic lock / reposition / strip or exchange over wire.
  • Outcome and plan if recurrent: ___.
18
Phase F · Level 18

High-Yield Cheat Sheet

Pre-rounds compression. Rules only.

Graft when veins too poor for fistula but inflow/outflow adequate.
Graft beats catheter (lower infection/mortality).
Graft: usable ~2 weeks; clots/stenoses more.
Graft lesion = venous anastomosis; surveil flow.
Catheter: right IJ > left IJ > femoral; never subclavian.
Subclavian = central stenosis.
Tunnel + cuff for anything beyond short-term.
Tip at cavoatrial junction; lock heparin/citrate.
Poor flow: thrombus / fibrin sheath / malposition.
Thrombolytic lock first; fibrin sheath → strip/exchange.
Reversed lines = recirculation, temporary only.
Rope-ladder after incorporation; never area puncture.
19
Phase F · Level 19

Flashcards

Active recall. At least one card per objective.

CARD 1

Q. When is an AV graft chosen?

Show answer

A. When veins are inadequate for a fistula but the inflow artery and outflow vein are adequate — and a graft is feasible.

DETAILED. A graft is preferred over a catheter for its lower infection and mortality.

CLINICAL. If neither fistula nor graft is possible, a catheter is used.

CARD 2

Q. Where do grafts characteristically stenose, and why?

Show answer

A. At the venous anastomosis, from neointimal hyperplasia.

DETAILED. Falling flow is the warning sign on surveillance.

CLINICAL. Treat with angioplasty before it thromboses.

CARD 3

Q. Compare a graft and a fistula.

Show answer

A. Graft: usable sooner (~2 weeks), no maturation, but lower patency and more interventions; fistula: better long-term, lowest infection.

DETAILED. Graft infection sits between fistula and catheter.

CLINICAL. Choose by vessels, timeline, and the access Life-Plan.

CARD 4

Q. Which catheter site is preferred, and which is avoided?

Show answer

A. Right internal jugular is preferred; the subclavian is avoided.

DETAILED. The subclavian causes central stenosis that can ruin the arm.

CLINICAL. Femoral is for temporary use and is infection-prone.

CARD 5

Q. Distinguish a tunneled-cuffed from a temporary catheter.

Show answer

A. Tunneled-cuffed: a tunnel and Dacron cuff lower infection/dislodgement, for longer use; temporary: non-tunneled, acute short-term only.

DETAILED. The cuff anchors the catheter and resists infection.

CLINICAL. Tip sits at the cavoatrial junction in both.

CARD 6

Q. How is poor catheter flow managed?

Show answer

A. Check position (radiograph); try a thrombolytic lock; for a recurrent fibrin sheath, strip or exchange over a wire.

DETAILED. Reversing the lines restores numbers but recirculates — only temporary.

CLINICAL. The cause guides the durable fix.

CARD 7

Q. What locking solutions are used, and why?

Show answer

A. Heparin or citrate between sessions to prevent thrombosis; an antimicrobial lock in selected high-risk patients.

DETAILED. The lock fills the lumens between treatments.

CLINICAL. It keeps the catheter patent until next use.

CARD 8

Q. How should a graft be cannulated?

Show answer

A. Only after incorporation (standard ~2 weeks), using rope-ladder along the graft.

DETAILED. Early cannulation causes haematoma; area puncture causes pseudoaneurysm.

CLINICAL. Early-cannulation grafts are the exception to the wait.

20
Phase F · Level 20

One-Minute Preceptor

Micro-teaching for rounds. Two scenarios, five steps each.

SCENE 1
The subclavian about to go in
GET A COMMITMENTAsk: “We're about to place a tunneled line via the subclavian — any objection?”
PROBE“What does the subclavian route risk for this patient?”
TEACHCentral stenosis that can ruin the arm for a future fistula or graft — use the right IJ.
REINFORCE“Right — site choice protects their access future.”
CORRECT ERRORSIf they defended the subclavian, point to central stenosis.
SCENE 2
The catheter that keeps clotting
GET A COMMITMENTAsk: “Good tip, lock works briefly but it keeps failing — what's the cause?”
PROBE“Why does a transient, recurrent lock response point away from simple thrombus?”
TEACHA fibrin sheath at the tip — strip or exchange over a wire rather than relock endlessly.
REINFORCE“Exactly — recurrent dysfunction with a good tip is a sheath.”
CORRECT ERRORSIf they reversed the lines as the fix, note the recirculation cost.
22
Phase F · Level 22

Board-Style Q&A

Eight items, each anchored in this chapter. At least one per objective.

Q 01
A patient's veins are inadequate for a fistula, but the inflow artery and outflow vein are adequate. The best access is:

Tap an option to check your answer

  • AA tunneled catheter
  • BAn AV graft
  • CA subclavian catheter
  • DNo access — reattempt a fistula later
Q 02
Where does an AV graft most characteristically stenose?

Tap an option to check your answer

  • AThe arterial anastomosis
  • BThe venous anastomosis (neointimal hyperplasia)
  • CThe mid-graft body
  • DThe skin entry site
Q 03
Which tunneled catheter site is preferred, and which must be avoided for chronic access?

Tap an option to check your answer

  • ASubclavian preferred; femoral avoided
  • BRight internal jugular preferred; subclavian avoided
  • CFemoral preferred; right IJ avoided
  • DLeft IJ preferred; right IJ avoided
Q 04
A tunneled catheter has poor flow; the chest radiograph shows a well-positioned tip and a thrombolytic lock works only briefly and recurrently. The likely cause is:

Tap an option to check your answer

  • AMalposition
  • BA fibrin sheath
  • CA kinked catheter
  • DReversed lines
Q 05
When should a standard AV graft first be cannulated?

Tap an option to check your answer

  • AImmediately after placement
  • BAfter incorporation (about two weeks)
  • COnly after three months
  • DNever — grafts are not cannulated
Q 06
A catheter gives poor flow only in certain body positions, and imaging suggests tip malposition. The correct step is:

Tap an option to check your answer

  • AAccept reversed lines permanently
  • BReposition the tip to the cavoatrial junction
  • CRemove the catheter immediately
  • DIncrease the heparin lock concentration
Q 07
Which practice protects an AV graft during cannulation?

Tap an option to check your answer

  • AArea puncture (same spot)
  • BRope-ladder along the graft
  • CCannulating before incorporation
  • DUsing the largest needle on day one
Q 08
In Flowchart 6.B, a poorly flowing catheter has a well-positioned tip and a thrombolytic lock fails to give durable flow. The pathway directs you to:

Tap an option to check your answer

  • AReverse the lines permanently
  • BStrip or exchange the catheter over a wire (fibrin sheath)
  • CRemove access and place a fistula today
  • DIncrease the dialysate flow